Gene Regulation & Epigenomics
DNA methylation · Genomic imprinting · Allele-specific expression · eQTLs · Gene regulatory networks (GRNs)
BioBix: Bioinformatics and Computational Genomics
The BioBix lab of Bioinformatics and Computational Genomics at Ghent University develops and applies novel data-analytical methods for omics data. We combine longstanding expertise in genome regulation and its disruption in cancer and aging with omics-based biomarker discovery and translational research, often in collaboration with clinical researchers.
Our research
Biological Aging
Organ-specific proteomic aging clocks · Epigenetic aging clocks
Cancer Genomics
Epigenetic dysregulation · Loss of imprinting · Allele-specific dysregulation
Proteogenomics
Ribosome profiling · Novel proteoforms · sORFs & micropeptides · Mass spectrometry · Long-read sequencing
Telomere Biology
Telomere attrition · Cardiovascular aging · Chromosome-arm- and allele-specific dynamics
Translational Omics & Molecular Diagnostics
Biomarker discovery · Molecular cancer diagnostics · Blood- & urine-based biomarkers
Selected publications
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Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements
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Population-level allelic dispersion modeling by maelstRom yields genome-wide maps of allele-specific dysregulation during early carcinogenesis
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MEXPRESS update 2019
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Telomere length as cardiovascular aging biomarker
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An update on sORFs.org : a repository of small ORFs identified by ribosome profiling
Resources
All resources
Our team
Meet the team
Interested in joining this team?
We welcome prospective PhD candidates and visiting researchers. Each year, we also dedicate time to training and guiding bachelor’s and master’s thesis students.